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KMID : 1188320160100020237
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Gut and Liver
2016 Volume.10 No. 2 p.237 ~ p.243
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Does Polyethylene Glycol (PEG) Plus Ascorbic Acid Induce More Mucosal Injuries than Split-Dose 4-L PEG during Bowel Preparation?
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Kim Min-Sung
Park Jong-Ha
Park Jae-Hyun
Kim Ji-Yeon
Choi Joon-Hyuk
Heo Nae-Yun
Park Seung-Ha
Kim Tae-Oh
Yang Sung-Yeon
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Abstract
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Background/Aims:The aims of this study were to compare the bowel-cleansing efficacy, patient affinity for the preparation solution, and mucosal injury between a split dose of poly-ethylene glycol (SD-PEG) and low-volume PEG plus ascorbic acid (LV-PEG+Asc) in outpatient scheduled colonoscopies.
Methods:Of the 319 patients, 160 were enrolled for SD-PEG, and 159 for LV-PEG+Asc. The bowel-cleansing efficacy was rated according to the Ottawa bowel preparation scale. Patient affinity for the preparation solution was assessed using a questionnaire. All mucosal injuries observed during colonoscopy were biopsied and histopathologically reviewed.
Results:There was no significant difference in bowel cleansing between the groups. The LV-PEG+Asc group reported better patient acceptance and preference. There were no significant differences in the incidence or characteristics of the mucosal injuries between the two groups.
Conclusions:Compared with SD-PEG, LV-PEG+Asc exhibited equivalent bowel-cleansing efficacy and resulted in improved patient acceptance and preference. There was no significant difference in mucosal injury between SD-PEG and LV-PEG+Asc. Thus, the LV-PEG+Asc preparation could be used more effectively and easily for routine colonoscopies without risking significant mucosal injury.
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KEYWORD
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Colonoscopy, Bowel preparation, Polyethylene glycols, Ascorbic acid, Mucosal injury
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